Our Arginine Alpha-Ketoglutarate (AAKG) is a 2:1 mixture of the amino acid arginine and alpha-ketoglutarate.
Alpha-ketoglutarate (AKG) is the deaminated carbon skeleton (missing the amino group) of the amino acids glutamic acid (aka glutamate) and glutamine. Alpha-ketoglutarate is also an intermediate in the Kreb’s cycle, a set of metabolic processes involved in energy (ATP) production from fats and carbohydrates, as well as amino acid metabolism. As such, AKG is an important metabolic link between cellular energy production and protein metabolism.
In states of high protein intake or simply during normal protein turnover, AKG receives the amino (nitrogen containing) groups from amino acids, forming glutamate, which then contributes to the urea cycle (where urea is produced and eventually lost in the urine). AKG can also be used in transamination reactions to generate arginine (as well as proline and histidine)(1). Mixing AKG with arginine would therefore favor less deamination of arginine, preserving it and prolonging its effects(2).
AAKG would be taken on an empty stomach (or at the beginning of meals), spread throughout the day at several doses of approximately 4 grams (depending on body size). During periods of weight loss, AAKG may help prevent muscle loss and could be used with supplements such as the Branch Chain Amino Acids, especially leucine, supplemental glutamine, and some form of creatine. When undergoing heavy or high overload training or when gastrointestinal stress is high (e.g., due to high caloric intake), AAKG may help with protein balance and digestive and absorptive function, and could be taken in conjunction with with Betaine HCL and/or protease. See also the supplement uses of arginine.